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Strontium Ranelate Active Pharmaceutical Ingredient Terbinafine HCL CAS 135459-87-9

Categories Active Pharmaceutical Ingredient
Brand Name: vanz
Model Number: 135459-87-9
Certification: ISO9001
Place of Origin: China
MOQ: 1kg
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 200kg per month
Delivery Time: 3-5 days
Packaging Details: bags or drum
Name: Terbinafine HCL
CAS: 135459-87-9
Appearance: White powder
COA: Available
Assay: 99%min
Stock: Available
Company Info.
Wuhan Vanz Pharm Inc.
Verified Supplier
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    Strontium Ranelate Active Pharmaceutical Ingredient Terbinafine HCL CAS 135459-87-9

    Strontium Ranelate Active Pharmaceutical Ingredient Terbinafine HCL CAS 135459-87-9


    Introduction


    Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).


    Basic Information


    Product NameStrontium ranelate
    Synonyms5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt (1:2)
    CAS NO.135459-87-9
    EINECS135459-87-9
    Molecular FormulaC12H6N2O8SSr2
    Molecular Weight513.491
    Specifications:
    StandardAssay ≥99%
    AppearanceWhite powder
    Test MethodHPLC
    Other information:
    Packing100G;500G;1Kg;25Kg(Export worthy packing)
    ApplicationsOsteoporosis Treatment
    StatusCommercials
    RemarkFor more details,please contact us

    Medical Uses


    Strontium ranelate is registered as a prescription drug in more than 70 countries for the treatment of post-menopausal osteoporosis to reduce the risk of vertebral and hip fractures. In the United Kingdom, strontium ranelate is prescribed under the National Health Service as a medicine for the treatment of post menopausal osteoporosis.


    • 2 major phase III clinical studies, SOTI (Spinal Osteoporosis Therapeutic Intervention) and TROPOS (Treatment of Peripheral Osteoporosis), were started in 2000 to investigate the efficacy of strontium ranelate in reducing vertebral fractures and peripheral fractures, including hip fractures.
    • In the 3 years results, reported in 2004, strontium ranelate showed significant reduction in vertebral fractures with 41% and hip fractures with 36% compared with patients treated with placebo.
    • The efficacy was sustained in 5 years data. The 5 years data confirmed that strontium ranelate can reduce the vertebral fractures significantly no matter the risk factors of the osteoporotic women have.

    Strontium ranelate shows anti-fracture efficacy in very old elderly and osteopenic patients.


    For 1% cream:

    • for adults and children 12 years and older:
      • wash the affected skin with soap and water and dry completely before applying
      • apply once a day to affected skin for 2 weeks or as directed by a doctor
      • wash hands after each use
    • children under 12 years: ask a doctor

    COA


    AppearanceOff-white or primrose yellow crystalline powder
    IdentificationPosive
    The spectrofram of the test solution corrsrponds to that of reference
    The retention time of the major peak of the test solution corresponds to that of the RS
    Acidity6.5-8.5
    Turbidity of solutionNot more opalescent that reference solution class 1
    Color of solutionNot more intensely colored that reference solution Y2
    Loss of dying20.0-23.5%
    ChloridesNo more than 0.1%
    Heavy metals(as Pb)No more than 20ppm
    ArsenicNo more than 0.0002%
    Strontium32.0-35.0%
    Related substances(HPLC)Any impurity NMT0.2%
    Total impurities NMT0.5%
    SolubilitySolute in 0.1mol/ hydrochloric acid solution, cery slightly solute in water, practically solute in methanol or acetate
    Assay(on dried basisi)Over 99.0%

    FAQ


    Q1: Are you a manufacturer ?

    A: Yes, our factory is located in Jiayu, Hubei, our lab located in Wuhan. But we also do some trading business.

    Q2: What`s your delivery

    A: We send goods in 3 working day after receiving your payment by DHL, FEDEX, TNT, EMS, AIR OR SEA as you request.

    Q3: What certificates and documents do you offer?

    A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

    Q4: Why should I choose you?

    A: Factory supply with the most compatitive price and high quality!!!

    Q5: Can I get best price from you?

    A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!

    Q6: How should I pay?

    A: We accept all kinds of payment ways. such as alibaba trade asssurance, T/T, West Union, Money Gram.

    Q7: Do you provide free sample?

    A: We can provide free sample of some chemicals and you just need you to cover the delivery cost.


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